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English Journal Article
2019
Zhang, L.; Guo, L.; Wu, H.; Gong, X.; Lv, J.; Yang, Y. Role of physical performance measures for identifying functional disability among chinese older adults: Data from the china health and retirement longitudinal study. Plos One 2019.
Zhou, J.; Fang, S. Association between undiagnosed hypertension and health factors among middle-aged and elderly chinese population. International Journal of Environmental Research and Public Health 2019.
Eggleston, K. China’s demographic change in comparative perspective: Implications for labor markets and sustainable development. Karen Eggleston 2019.
Bernard, A.; Bell, M.; Zhu, Y. Migration in china: A cohort approach to understanding past and future trends. Wiley 2019.
Hao, X.; Yang, Y.; Gao, X.; Dai, T. Evaluating the effectiveness of the health management program for the elderly on health-related quality of life among elderly people in china. International journal of environmental research and public health 2019.
You, X.; Zhang, Y.; Zeng, J.; Wang, C.; Sun, H.; Ma, Q.; Ma, Y.; Xu, Y. Disparity of the chinese elderly’s health-related quality of life between urban and rural areas a mediation analysis. BMJ Open 2019.
Touyz, R.M. Hypertension guidelines: Impact of blood pressure targets. C
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Abstract
Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally regulate each other, are among the well-known cancer hallmarks. Recent evidence suggests that many metabolites serve as substrates or cofactors of chromatin-modifying enzymes as a consequence of the translocation or spatial regionalization of enzymes or metabolites. Various metabolic alterations and epigenetic modifications also reportedly drive immune escape or impede immunosurveillance within certain contexts, playing important roles in tumor progression. In this review, we focus on how metabolic reprogramming of tumor cells and immune cells reshapes epigenetic alterations, in particular the acetylation and methylation of histone proteins and DNA. We also discuss other eminent metabolic modifications such as, succinylation, hydroxybutyrylation, and lactylation, and update the current advances in metabolism- and epigenetic modification-based therapeutic prospects in cancer.
Supplementary Information
The online version contains supplementary material available at (10.1007/s13238-021-00846-7) contains supplementary material, which is available to authorized users.
Keywords: metabolic reprogramming, epigenetics, tumorigenesis, tumor immunity, cancer therapy
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