Farhat bouallagui biography of christopher
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Identifying mutations in Tunisianfamilies with retinal dystrophy.
PubMed
Habibi, Imen; Chebil, Ahmed; Falfoul, Yosra; Allaman-Pillet, Nathalie; Kort, Fedra; Schorderet, Daniel F; El Matri, Leila
Retinal dystrophies (RD) are a rare genetic disorder with high genetic heterogeneity. This study aimed at identifying disease-causing variants in fifteen consanguineous Tunisianfamilies. Full ophthalmic examination was performed. Index patients were subjected to IROme analysis or whole exome sequencing followed by homozygosity mapping. All detected variations were confirmed by direct Sanger sequencing. Mutation analysis in our patients revealed two compound heterozygous mutations p.(R91W);(VD) in RPE65, and five novel homozygous mutations: in CNGB1, in PDE6B, splice site variant cA > G and c_delGAAG in FAMA and c + 3_ + 6delAAGT in CERKL. The latter mutation impacts pre-mRNA splicing of CERKL. The other changes detected were six previously reported mutations in CNGB3 (p.R*), ABCA4 (p.W*), NR2E3 (), RPE65 (), PROM1 (cdupT) and EYS (cA > G). Segregation analysis in each family showed that all affected individuals were homozygotes and unaffected individuals were either heterozygote carriers or homozygous wild type allele. These results confirm the involvement of a large number of ge
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Empire (Kasabian song)
single by Kasabian
"Empire" is a song by English rock band Kasabian, included as the title track for their second studio album, Empire (). It was released 24 July as the lead single from that album on CD. The single became popular immediately, entering the UK Singles Chart at number nine, its peak position, making it the band's third UK top-ten single. On 21 August , inch and DVD versions of the single were released.
The song was available as a pre-order on the band's website which also included a free download of their cover of David Bowie's "Heroes", which was used for ITV's coverage of the FIFA World Cup. It was also used during series 9 of Top Gear.
Background
[edit]Guitarist Sergio Pizzorno said,
'Empire' is about disobeying orders; it's about the middle finger to the machine. We are in a rock 'n' roll band; we are outlaws - we are bandits and we are pirates. We earn a living from being musicians - now that to me is amazing and now 'Empire' - we used this as a metaphor in war to disobey the generals when the order was given and the lads said: 'You know what? 'Fuck 'em, I'm not doing what you say anymore'[2]
Composition
[edit]"Empire" is one of Kasabian's first songs to include a live string section, which would be a